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mPEG-DPPE is a phospholipid PEG conjugate that is both hydrophilic and hydrophobic. PEGylated phospholipids are excellent liposome forming materials and can also be used for drug delivery, gene transfection and vaccine delivery (e.g. COVID-19 mRNA vaccines). PEGylation of phospholipids greatly improves the circulation time and stability of the encapsulated drugs. These materials can also be used for targeted drug delivery by modifying their surfaces with targeting ligands (e.g., antibodies, peptides).
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