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4-arm PEG succinimidyl succinate ester (4-arm PEG-SS) is a multiarm PEG derivative with succinimidyl NHS active ester groups at each terminal of the 4 arms connected to onepentaerythritol core. PEG-SS (succinimidyl succinate ester) is one type of PEG-NHS reagents. There is a C2 hydrocarbon ester linkage between PEG and the NHS ester. NHS is a good leaving group which can react with amine-containing moities.
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