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Biotin capped 4-arm poly(lactide-co-glycolide) (4-arm PLGA-Biotin) is a multiarm PLGA derivative with biotin groups at each terminal of the four arms connected to one pentaerythritol core. Biotin can bind to streptavidin and avidin with high affinity and specificity. Biotin is conjugated to a linear PLGA through a stable amide linker. Otherwise noted, multiarm PLGA is composed of d,l-lactide and glycolide (50:50 ratio).
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