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Carboxylic acid terminated 4-arm poly(lactide-co-glycolide) (4-arm PLGA-COOH) is a multiarm PLGA derivative with amine groups at each terminal of the four arms connected to one pentaerythritol core. PEG acid can be used to react with amine groups with peptide coupling reagents such as NHS and DCC, EDC. Otherwise noted, multiarm PLGA is composed of d,l-lactide and glycolide (50:50 ratio).
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