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Carboxyl Iron Oxide Nanoparticles are superparamagnetic particles with excellent colloidal stability and biocompatible coating for biomedical applications including: in-vivo magnetic resonance imaging (MRI), magnetic particles imaging (MPI), magnetic sensing for in-vitro diagnostics, small molecular drug delivery, immunotherapy, hyperthermia, adjuvant for vaccine, etc. Carboxyl magnetic nanoparticles are nanosized (5-30 nm) iron oxide particles with carboxylic acid groups. Oligonucleotides, antibodies, or other ligands with amine groups can be easily coupled to the nanoparticles. Activation through EDC is required. With excellent colloidal stability and unique surface coating, the carboxyl magnetic nanoparticles exhibit good binding capacity and low non-specific binding of protein or nucleic acids.
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