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Cholesterol functionalized polyethylene glycol with conjugated terminal biotin (Cholesterol-PEG-BIO, cholesterol-PEG-Biotin), is a lipophilic lipid PEG conjugate with good water solubility. PEG cholesterol derivatives can be used to make targeted liposome to improve circulation time for encapsulated drugs. They may also be used for non-viral transfection reagents. The biotin-functionalized nanoparticles can bind to streptavidin and avidin with high affinity and specificity
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