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Cholesterol functionalized polyethylene glycol with conjugated vinylsulfone (Cholesterol-PEG-VS), is a lipophilic lipid PEG conjugate with good water solubility. PEG cholesterol derivatives can be used to make targeted liposome to improve circulation time for encapsulated drugs. They may also be used for non-viral transfection reagents. The vinylsulfone-functionalized nanoparticles can be modified by thiol-containing moieties.
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