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1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine (DSPE) conjugated polyethylene glycol with iodoacetyl (DSPE-PEG-IA) is a linear heterobifunctional PEGylation reagent with a DSPE phospholipid and an iodoacetyl group. Iodoacetyl (IA) is a thiol (-SH) reactive group that can be used to modify biomolecules or other materials via their available thiol groups. Iodine group can be easily replaced by thiol group to form a stable carbon thiol bond. DSPE-PEG-IA is used to prepare micelles or liposomes with Iodoacetyl group on the particle surface for bioconjugation via thiol substitution.
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