신고사유
신고해주신 내용은 쇼핑몰 운영자의 검토 후 내부 운영 정책에 의해 처리가 진행됩니다.
Clonality | Polyclonal |
Isotype | IgG |
Concentration | 1.45 mg/mL |
Storage | Store at -20℃. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4 |
Purification Method | Affinity purification |
Research Areas | Cancer, Epigenetics and Nuclear Signaling |
Conjugation | Unconjugated |
Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse HMGB1 |
Abbre | HMGB1 |
Synonyms | Amphoterin,Chromosomal protein,nonhistone,HMG1,DKFZp686A04236,High mobility group 1,High mobility group box 1,High mobility group protein 1,High mobility group protein B1,high-mobility group (nonhistone chromosomal) protein 1,HMG-1,HMG1,HMG3,HMGB 1,HMGB1,HMGB1,NONHISTONE CHROMOSOMAL PROTEIN HMG1,SBP 1,Sulfoglucuronyl carbohydrate binding protein |
Swissprot | P09429,P63158,P63159 |
Calculated MW | 25kDa |
Observed MW | 25kDa |
Cellular Localization | Nucleus. Chromosome. Cytoplasm. Secreted. Cell membrane. Endosome. Endoplasmic reticulum-Golgi intermediate compartment. In basal state predominantly nuclear. Shuttles between the cytoplasm and the nucleus (PubMed:12231511, PubMed:17114460). Translocates from the nucleus to the cytoplasm upon autophagy stimulation (PubMed:20819940). Release from macrophages in the extracellular milieu requires the activation of NLRC4 or NLRP3 inflammasomes (By similarity). Passively released to the extracellular milieu from necrotic cells by diffusion, involving the fully reduced HGMB1 which subsequently gets oxidized (PubMed:19811284). Also released from apoptic cells (PubMed:16855214, PubMed:18631454). Active secretion from a variety of immune and non-immune cells such as macrophages, monocytes, neutrophils, dendritic cells and natural killer cells in response to various stimuli such as LPS and cytokines involves a nonconventional secretory process via secretory lysosomes (PubMed:12231511, PubMed:14532127, PubMed:15944249). Secreted by plasma cells in response to LPS (By similarity). Found on the surface of activated platelets (PubMed:11154118). |
Tissue Specificity | Ubiquituous. Expressed in platelets (PubMed:11154118).Highest expression level in kidney. |
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