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Orthopyridyl disulfide capped poly-L-Glutamic acid (OPSS-poly-L-Glutamic acid, OPSS-PGlu, Pyridylthio-PGlu) is a negatively charged synthetic polyamino acid. It is a crystalline solid soluble in water. Applications for poly-L-glutamic acid include the conjugation to active molecules for improved activities and the layer-by-layer deposition techniques for surface coating.
Orthopyridyl disulfide or pyridyldithio (OPSS) functionalized polymers can selectively reacts with free thiol, SH, sulfhydryl or mercapto to form a oxidation, reduction reversible disulfide bond.
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