신고사유
신고해주신 내용은 쇼핑몰 운영자의 검토 후 내부 운영 정책에 의해 처리가 진행됩니다.
Clonality | Polyclonal |
Isotype | IgG |
Concentration | 0.89 mg/mL |
Storage | Store at -20℃. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4 |
Purification Method | Affinity purification |
Research Areas | Cancer, Cell Biology, Epigenetics and Nuclear Signaling |
Conjugation | Unconjugated |
Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse P27 KIP1 |
Abbre | p27 |
Synonyms | AA408329,AI843786,Cdki1b,CDKN 1B,CDKN 4,CDKN1B,CDKN4,CDN1B,Cyclin Dependent Kinase Inhibitor 1B,Cyclin dependent kinase inhibitor p27,Cyclin-dependent kinase inhibitor 1B (p27,Kip1),Cyclin-dependent kinase inhibitor 1B,Cyclin-dependent kinase inhibitor p27,Cyclin-dependent kinase inhibitor p27 Kip1,KIP 1,KIP1,MEN1B,MEN4,OTTHUMP00000195098,OTTHUMP00000195099,p27,p27 Kip1,P27-like cyclin-dependent kinase inhibitor,p27Kip1 |
Swissprot | P46527,P46414 |
Cellular Localization | Nucleus. Cytoplasm. Endosome. Nuclear and cytoplasmic in quiescent cells. AKT-or RSK-mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6 and this leads to lysosomal degradation. |
Tissue Specificity | Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.Highest expression level in pigmented layer of retina. |
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