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Poly(L-lactide-co-glycolide)-b-poly(ethylene glycol)-vinylsulfone (PLGA-PEG-VS) is a functional amphiphilic block copolymer with vinylsulfone group at the end of PEG. Vinylsulfone groups are useful for coupling via Michael addition reactions with thiol. PLGA-PEG-VS is used to prepare micelles or nanoparticles with vinylsulfone on the micelle surface for bioconjugation. Hydrophobic drugs is encapsulated in the PLGA core for targeted drug delivery.
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